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You should not touch the area that you put the Frontline on for 12-24 hours or so. Other than that......kiss away!

I always put Pico's Advantage on at night because I forget and kiss him every time I pick him up. Yuck! Got some right on my lips one time. I'm still alive but it felt strange until I washed it off and then my lips were a little numb feeling.
 
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