geeezzz, why didn't you had them neutered and spayed ? or at least have the boy neutered before putting him together with your unspayed female ? I can't give you advice I am not a breeder. I just hope everything goes well for your female. How big is Izzy ? With 5 or 6 pups if she is on the small side she might need a C section. Keep your vet's phone number handy.